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14-3-3 Protein Cerebrspinal Fluid Detection in Human Growth Hormone-Treated Creutzfeldt-Jakob Disease Patients Ann Neurol 49:257-260, Brandel,J.,et al, 2001 See this aricle in Pubmed Article Abstract The usefulness of the detection of 14-3-3 protein in the cerebrospinal fluid (CSF) in the diagnosis of Creutzfeldt-Jakob disease transmitted from human growth hormone was evaluated in 20 French patients. The 14-3-3 protein was rarely detect able within the first 3 months of the disease but always positive after 7 months associated with the aggravation of the disease and the occurrence of dementia. 14-3-3 detection was not predictive of the survival time of the patients. The genotype at PRN P codon 129 could influence the timing of appearance of the 14-3-3 protein in the CSF.

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(click to filter results - removes previous filter) growth hormone iatrogenic neurologic disorders Jakob-Creutzfeldt disease pituitary,hormones of protein 14-3-3,cerebrospinal fluid

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